AustralieFrV1, Main, Exploration, bibRecord, 006223

Association of Plasma Aß Peptides with Blood Pressure in the Elderly

Identifieur interne : 006223 ( Main/Exploration ); précédent : 006222; suivant : 006224

Association of Plasma Aß Peptides with Blood Pressure in the Elderly

Auteurs : Jean-Charles Lambert [France] ; Jean Dallongeville [France] ; Kathryn A. Ellis [Australie] ; Susanna Schraen-Maschke [France] ; James Lui [Australie] ; Simon Laws [Australie] ; Julie Dumont [France] ; Florence Richard [France] ; Dominique Cottel [France] ; Claudine Berr [France] ; David Ames [Australie] ; Colin L. Masters [Australie] ; Christopher C. Rowe [Australie] ; Cassandra Szoeke [Australie] ; Christophe Tzourio [France] ; Jean-François Dartigues [France] ; Luc Buée [France] ; Ralph Martins [Australie] ; Philippe Amouyel [France]

Source :

PLoS ONE [ 1932-6203 ] ; 2011.

RBID : PMC:3078119

Abstract

Background

Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion.

We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively).

Methodology/Principal Findings

Plasma Aß_1-40 and Aß_1-42 levels were measured using an xMAP-based assay in 1,972 individuals (none of whom were taking antihypertensive drugs) from 3 independent studies: the French population-based 3C and MONA-LISA (Lille) studies (n = 627 and n = 769, respectively) and the Australian, longitudinal AIBL study (n = 576). In the combined sample, the Aß_1-42/ Aß_1-40 ratio was significantly and inversely associated with SBP (p = 0.03) and a similar trend was observed for DBP (p = 0.06). Using the median age (69) as a cut-off, the Aß_1-42/Aß_1-40 ratio was strongly associated with both SBP and DBP in elderly individuals (p = 0.002 and p = 0.03, respectively). Consistently, a high Aß_1-42/ Aß_1-40 ratio was associated with a lower risk of hypertension in both the combined whole sample (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.56-0.90) and (to an even greater extent) in the elderly subjects (OR, 0.53; 95% CI, 0.37–0.75). Lastly, all these associations appeared to be primarily driven by the level of plasma Aß_1-40.

Conclusion

The plasma Aß_1-42/Aß_1-40 ratio is inversely associated with SBP, DBP and the risk of hypertension in elderly subjects, suggesting that Aß peptides affect blood pressure in vivo. These results may be particularly relevant in Alzheimer's disease, in which a high Aß_1-42/Aß_1-40 plasma ratio is reportedly associated with a decreased risk of incident disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078119

DOI: 10.1371/journal.pone.0018536
PubMed: 21525986
PubMed Central: 3078119

Affiliations:

Le document en format XML

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<author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name>
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<author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
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<author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name>
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</nlm:aff>
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<author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name>
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</nlm:aff>
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<author><name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name>
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</nlm:aff>
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</nlm:aff>
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<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
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<author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
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<author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buée">Luc Buée</name>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
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</nlm:aff>
<country xml:lang="fr">France</country>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire, Lille</wicri:regionArea>
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<author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
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<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
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<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
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</placeName>
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</nlm:aff>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
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</placeName>
</affiliation>
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</nlm:aff>
<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Plasma Aß Peptides with Blood Pressure in the Elderly</title>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
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<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
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<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
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<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Psychiatry, University of Melbourne, St George's Hospital, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Mental Health Research Institute, University of Melbourne, Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Mental Health Research Institute, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>National Ageing Research Institute, Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Ageing Research Institute, Parkville, Victoria</wicri:regionArea>
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</author>
<author><name sortKey="Schraen Maschke, Susanna" sort="Schraen Maschke, Susanna" uniqKey="Schraen Maschke S" first="Susanna" last="Schraen-Maschke">Susanna Schraen-Maschke</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
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<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>INSERM U837, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U837, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Centre Hospitalier Régional Universitaire, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Lui, James" sort="Lui, James" uniqKey="Lui J" first="James" last="Lui">James Lui</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laws, Simon" sort="Laws, Simon" uniqKey="Laws S" first="Simon" last="Laws">Simon Laws</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dumont, Julie" sort="Dumont, Julie" uniqKey="Dumont J" first="Julie" last="Dumont">Julie Dumont</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM U744, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
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<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Centre Hospitalier Régional Universitaire, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cottel, Dominique" sort="Cottel, Dominique" uniqKey="Cottel D" first="Dominique" last="Cottel">Dominique Cottel</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>INSERM, U888, Université de Montpellier 1, Montpellier, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U888, Université de Montpellier 1, Montpellier</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Psychiatry, University of Melbourne, St George's Hospital, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Psychiatry, University of Melbourne, St George's Hospital, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>National Ageing Research Institute, Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Ageing Research Institute, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Mental Health Research Institute, University of Melbourne, Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Mental Health Research Institute, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Neurosciences, University of Melbourne, Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Neurosciences, University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name>
<affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Austin Health, Heidelberg, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Austin Health, Heidelberg, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>National Ageing Research Institute, Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Ageing Research Institute, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Australian Commonwealth Scientific and Research Organisation (CSIRO), Parkville, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian Commonwealth Scientific and Research Organisation (CSIRO), Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3"><nlm:aff id="aff15"><addr-line>INSERM U708, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U708, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<affiliation wicri:level="3"><nlm:aff id="aff16"><addr-line>INSERM U593, Victor Segalen University, Bordeaux, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U593, Victor Segalen University, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buée">Luc Buée</name>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>INSERM U837, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U837, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Centre Hospitalier Régional Universitaire, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir James McCusker Alzheimer's Research Unit, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INSERM U744, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Université Lille Nord de France, UDSL, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Centre Hospitalier Régional Universitaire, Lille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion.</p>
<p>We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively).</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>Plasma Aß<sub>1-40</sub>
 and Aß<sub>1-42</sub>
 levels were measured using an xMAP-based assay in 1,972 individuals (none of whom were taking antihypertensive drugs) from 3 independent studies: the French population-based 3C and MONA-LISA (Lille) studies (n = 627 and n = 769, respectively) and the Australian, longitudinal AIBL study (n = 576). In the combined sample, the Aß<sub>1-42</sub>
/ Aß<sub>1-40</sub>
 ratio was significantly and inversely associated with SBP (p = 0.03) and a similar trend was observed for DBP (p = 0.06). Using the median age (69) as a cut-off, the Aß<sub>1-42</sub>
/Aß<sub>1-40</sub>
 ratio was strongly associated with both SBP and DBP in elderly individuals (p = 0.002 and p = 0.03, respectively). Consistently, a high Aß<sub>1-42</sub>
/ Aß<sub>1-40</sub>
 ratio was associated with a lower risk of hypertension in both the combined whole sample (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.56-0.90) and (to an even greater extent) in the elderly subjects (OR, 0.53; 95% CI, 0.37–0.75). Lastly, all these associations appeared to be primarily driven by the level of plasma Aß<sub>1-40</sub>
.</p>
</sec>
<sec><title>Conclusion</title>
<p>The plasma Aß<sub>1-42</sub>
/Aß<sub>1-40</sub>
 ratio is inversely associated with SBP, DBP and the risk of hypertension in elderly subjects, suggesting that Aß peptides affect blood pressure <italic>in vivo</italic>
. These results may be particularly relevant in Alzheimer's disease, in which a high Aß<sub>1-42</sub>
/Aß<sub>1-40</sub>
 plasma ratio is reportedly associated with a decreased risk of incident disease.</p>
</sec>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Hauts-de-France</li>
<li>Languedoc-Roussillon</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Aquitaine</li>
<li>Occitanie (région administrative)</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bordeaux</li>
<li>Lille</li>
<li>Melbourne</li>
<li>Montpellier</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Hauts-de-France"><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
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<name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name>
<name sortKey="Schraen Maschke, Susanna" sort="Schraen Maschke, Susanna" uniqKey="Schraen Maschke S" first="Susanna" last="Schraen-Maschke">Susanna Schraen-Maschke</name>
<name sortKey="Schraen Maschke, Susanna" sort="Schraen Maschke, Susanna" uniqKey="Schraen Maschke S" first="Susanna" last="Schraen-Maschke">Susanna Schraen-Maschke</name>
<name sortKey="Schraen Maschke, Susanna" sort="Schraen Maschke, Susanna" uniqKey="Schraen Maschke S" first="Susanna" last="Schraen-Maschke">Susanna Schraen-Maschke</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name>
</region>
<name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
<name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
<name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name>
<name sortKey="Ellis, Kathryn A" sort="Ellis, Kathryn A" uniqKey="Ellis K" first="Kathryn A." last="Ellis">Kathryn A. Ellis</name>
<name sortKey="Laws, Simon" sort="Laws, Simon" uniqKey="Laws S" first="Simon" last="Laws">Simon Laws</name>
<name sortKey="Laws, Simon" sort="Laws, Simon" uniqKey="Laws S" first="Simon" last="Laws">Simon Laws</name>
<name sortKey="Lui, James" sort="Lui, James" uniqKey="Lui J" first="James" last="Lui">James Lui</name>
<name sortKey="Lui, James" sort="Lui, James" uniqKey="Lui J" first="James" last="Lui">James Lui</name>
<name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name>
<name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name>
<name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name>
<name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name>
<name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name>
<name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name>
<name sortKey="Szoeke, Cassandra" sort="Szoeke, Cassandra" uniqKey="Szoeke C" first="Cassandra" last="Szoeke">Cassandra Szoeke</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006223 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3078119
   |texte=   Association of Plasma Aß Peptides with Blood Pressure in the Elderly
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:21525986" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Association of Plasma Aß Peptides with Blood Pressure in the Elderly

Association of Plasma Aß Peptides with Blood Pressure in the Elderly

Source :

Abstract

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Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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